α / ß + CD 4 - CD 8 - double - negative T cells in patients with autoimmune lymphoproliferative syndrome ( ALPS ) express restricted Vß TCR diversity and are clonally related to CD 8 + T cells
نویسندگان
چکیده
* Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, 28 rue du Dr. Roux, 75015 Paris † INSERM U668, F-75015 Paris, France ‡ INSERM U768, Paris F-75015; Université René Descartes-Paris 5, Paris F-75006, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015 Paris, France § UMR INSERM U866, F-21079 Dijon, France; IFR-100 University of Burgundy, F-21079 Dijon, France, CHU, Dijon Cedex, France
منابع مشابه
Double - Negative ( CD 4 - CD 8 - ) T Cells From Adult T - ce l l Leukemia Patients Also Have Poor Expression of the T - ce l l Receptor ap / CD 3 Complex
We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8[doublenegative, DN], T-cell receptor [TCR] &). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no difference between DN-ATL and CD4+ATL patients. In contrast to typical CD4+ATL cells, DN-ATL cell...
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In autoimmune/lymphoproliferative syndrome (ALPS), defective Fas death receptor function causes lymphadenomegaly/splenomegaly, the expansion of T-cell receptor αβ(+) CD4/CD8 double-negative T cells, and frequent development of hematologic autoimmunity. Dianzani autoimmune lymphoproliferative disease (DALD) has a similar phenotype but lacks the expansion of double-negative T cells. This work sho...
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متن کاملDouble - Negative ( CD 4 - CD 8 - ) T Cells From Adult T - ce l l Leukemia Patients Also Have Poor
We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8[doublenegative, DN], T-cell receptor [TCR] &). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no difference between DN-ATL and CD4+ATL patients. In contrast to typical CD4+ATL cells, DN-ATL cell...
متن کاملDouble - Negative ( CD 4 - CD 8 - ) T Cells From Adult T - ce l l Leukemia Patients
We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8[doublenegative, DN], T-cell receptor [TCR] &). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no difference between DN-ATL and CD4+ATL patients. In contrast to typical CD4+ATL cells, DN-ATL cell...
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